Took diflucan still burning

Took diflucan still burning

  • Took diflucan still burning

    • Location: New York, NY
    • Developer: The Athena Group (Gary Davis at Athena)
    • Size: 97,000 sf
    • Project Cost: $75M
    • Status: Completed 2007
    In January of 2005, Gary Davis, as the Executive Vice President of the Athena Group, sourced this opportunity located on the northeast corner of Lenox Avenue and Central Park North. Mr. Davis acquired the property and directed the design and construction of 111 Central Park North, a 19 story, 47 unit condominium complex. The building also features 9,000 sf of ground floor retail, a fitness center and a wrap around landscaped terrace with an adjacent party room.
  • Took diflucan still burning

    • Location: Jersey City, NJ
    • Developer: The Athena Group (Ken Browne at Athena)
    • Size: 250,000 sf
    • Project Cost: $135M
    • Status: Completed 2007
    In March of 2004, Ken Browne, as Senior Vice President of Acquisitions and Development of the Athena Group, sourced this property located one block from the Jersey City Waterfront. Mr. Browne acquired the property and directed the overall development with a total cost in excess of $130 million. The project includes a 34 story tower with 250 condominium units, 10,500 square feet of retail and a 238 space parking garage.
  • Took diflucan still burning

    • Location: New York, NY
    • Developer: The Athena Group (Gary Davis at Athena)
    • Size: 98,000 sf
    • Project Cost: $92M
    • Status: Completed 2006
    In May of 2001, Gary Davis, as the Executive Vice President of the Athena Group, led the development of 43 West 64th in New York City. Mr. Davis directed the design and redevelopment of the project to have an exterior courtyard in the middle of the building to create a 12 story residential building with 33 luxury residential units comprising 86,000 sf and 12,000 sf of restaurant retail space.
  • Took diflucan still burning

    • Location: New York, NY
    • Developer: Forest City Ratner(Kenneth P Browne at FCR)
    • Size: 370,000 sf
    • Project Cost: $200M
    • Status: Completed 2003
    Kenneth P Browne oversaw construction of this luxury high rise consisting of 330 rental units and 2 levels of parking. Located in the Tribeca neighborhood, it is within walking distance of Soho, Chinatown and City Hall.
  • Took diflucan still burning

    • Location: New York, NY
    • Developer: The Related Companies (Ken Browne at HRH)
    • Size: 285,000 sf
    • Project Cost: $5.5M
    • Status: Completed June 2002
    Ken Browne, as a Senior Vice President of HRH Construction Corporation, oversaw the development of this 15 story mixed-use 80/20 luxury residential building. The limestone and brick structure includes 263 rental units with underground parking, a marble lobby, health club and retail space at ground level.
  • Took diflucan still burning

    • Location: New York, NY
    • Developer: The Athena Group (Gary Davis at Athena)
    • Size: 60,000 sf
    • Project Cost: $100M
    • Status: Completed 2001
    In 1999, Gary Davis, as Executive Vice President of the Athena Group directed the redevelopment of 838 Fifth Avenue, a residential project in New York City. The building, originally a 50,000 sq. ft. office building was combined with an adjacent townhouse and redesigned as a residential condominium at 65th Street and Fifth Avenue, New York City's premier Fifth Avenue residential address.
  • Took diflucan still burning

    • Location: New York, NY
    • Developer: The Related Companies (Ken Browne at HRH)
    • Size: 365,000 sf
    • Project Cost: $75M
    • Status: Completed May 2001
    Ken Browne, as a Senior Vice President of HRH Construction Corporation, oversaw the construction of a 34-story luxury condominium tower in Manhattan’s prestigious Upper East Side. The brick and limestone clad structure houses 94 apartments ranging in size from 1,100 to 3,827 sf. Each unit also has individually controlled heating and air conditioning.
  • Took diflucan still burning

    • Location: Queens, NY
    • Developer: Edward J Minskoff Equities (Gary Davis at Minskoff)
    • Size: 240,000 sf
    • Project Cost: $46M
    • Status: Completed 2000
    In 1997, Gary Davis, the Senior Vice President of Development at Edward J Minskoff Equities, oversaw the acquisition of eight acres of city-owned land adjacent to JFK International Airport from the New York City Economic Development Corporation for the construction of an administrative office building for the Federal Aviation Administration. The facility contains five levels of rentable space with parking for 815 vehicles.
  • Took diflucan still burning

    • Location: New York, NY
    • Developer: The Related Companies (Ken Browne at HRH)
    • Size: 400,000 sf
    • Project Cost: $75M
    • Status: Completed Aug 1999
    Ken Browne, as a Vice President for HRH Construction Corporation, oversaw the construction a 27-story residential rental building located in Battery Park City, New York, overlooking the Hudson River. Amenities include health club with swimming pool, private garden and below grade parking, as well as 1,200 sf. of retail space.
  • Took diflucan still burning

    • Location: New York, NY
    • Developer: Ian Schrager Hotels (Gary Davis)
    • Size: 500,000 sf
    • Project Cost: $150M
    • Status: Complete
    In 1998, Gary Davis, as the Executive Vice President of Development for Ian Schrager Hotels led the development of the 1,000 room Hudson Hotel in Manhattan. The original 1928 YWCA was transformed into a young, hip hotel featuring exquisitively designed cherry paneled rooms resembling Victorian ship cabins.
  • Took diflucan still burning

    • Location: New York, NY
    • Developer: The Related Companies (Ken Browne at HRH)
    • Size: 200,000 sf
    • Project Cost: $40M
    • Status: Completed Nov 1998
    Ken Browne, as a Vice President of HRH Construction Corporation, oversaw the development of a 22-story mixed-use luxury residential building. The structure's upper 13 floors are cantilevered over a neighboring 6-story building. The 246 apartments range in size from junior one-bedrooms to two-bedrooms. The structure features a 2,700 sf. health club, 3,000 sf. rooftop terrace with a glass-enclosed solarium, and 40,000 sf of retail space.
  • Took diflucan still burning

    • Location: New York, NY
    • Developer: The Related Companies (Ken Browne at HRH)
    • Size: 500,000 sf
    • Project Cost: $75M
    • Status: Completed Sept 1998
    Ken Browne, as a Vice President of HRH Construction Corporation, oversaw the construction of a 33 story mixed use building adjacent to Union Square Park. The building was completed in two phases. The first phase consisted of the core and shell construction of the 6-story retail component for such tenants as United Artist Theaters, Circuit City and Virgin Records. The second phase involved the construction of the 240-unit residential tower on top of the occupied retail space.
  • Took diflucan still burning

    • Location: New York, NY
    • Developer: Edward J Minskoff Equities (Gary Davis at Minskoff)
    • Size: 1,000,000 sf
    • Project Cost: $37M
    • Status: Completed 1995
    In 1994, Gary Davis, as Senior Vice President of Development at Edward J Minskoff Equities, oversaw the repositioning of the 1,000,000 rentable square foot, landmark corporate headquarters for the International Business Machines Corporation into a multi-tenant office building at 57th and Madison Avenue. Mr. Davis orchestrated the redesign of all of the ground floor public and retail spaces together with the building's mechanical and security systems to accommodate the new occupancy.
  • Diflucan tablets buy

    Elon Musk on Friday unveiled a coin-sized prototype of a brain implant developed by his startup Neuralink to enable people who are paralyzed to operate smartphones and robotic limbs with their thoughts — and said the company had worked to “dramatically http://www.urbandp.com/diflucan-online-without-prescription/ simplify” the device since presenting an earlier version last summer.In an event live-streamed on YouTube to more than 150,000 viewers at one point, the company staged a demonstration in which it trotted out a pig named Gertrude that was said to have had the company’s device diflucan tablets buy implanted in its head two months ago. The live stream showed what Musk claimed to be Gertrude’s real-time brain activity as it sniffed around a pen. At no point, though, did diflucan tablets buy he provide evidence that the signals — rendered in beeps and bright blue wave patterns on screen — were, in fact, emanating from the pig’s brain.A pig presented at a Neuralink demonstration was said to have one of the company’s brain implants in its head. YouTube screenshot“This is obviously sounding increasingly like a Black Mirror episode,” Musk said at one point during the event as he responded affirmatively to a question about whether the company’s implant could eventually be used to save and replay memories.

    €œThe future’s going to be weird.”advertisement Musk said that in July Neuralink received a breakthrough device designation from the Food and Drug Administration — diflucan tablets buy a regulatory pathway that could allow the company to soon start a clinical trial in people with paraplegia and tetraplegia. The big reveal came after four former Neuralink employees told STAT that the company’s leaders have long fostered an internal culture characterized by rushed timelines and the “move fast and break things” ethos of a tech company — a pace sometimes at odds with the slow and incremental pace that’s typical of medical device development. Advertisement Friday’s event began, 40 minutes late, with a glossy video about the company’s work — and then panned to Musk, standing in front of a blue curtain beside a gleaming new version of the company’s surgical diflucan tablets buy “sewing machine” robot that could easily have been mistaken for a giant Apple device. Musk described the event as a “product demo” and said its primary purpose was to recruit potential new employees.

    It was unclear whether the demonstration was diflucan tablets buy taking place at the company’s Fremont, Calif., headquarters or elsewhere. Musk proceeded to reveal the new version of Neuralink’s brain implant, which he said was designed to fit snugly into the top of the skull. Neuralink’s technological diflucan tablets buy design has changed significantly since its last big update in July 2019. At that time, the company’s brain implant system involved a credit-card sized device designed to be positioned behind the back of a person’s ear, with several wires stretching to the top of the skull.

    After demonstrating the pig’s brain activity at Friday’s event, Musk showed video footage of a pig walking on a treadmill and said Neuralink’s device could be used to “predict the position of limbs with high accuracy.” That capability would be critical to allowing someone using the device to do something like controlling a prosthetic limb, for example.Neuralink for months has signaled that diflucan tablets buy it initially plans to develop its device for people who are paralyzed. It said at its July 2019 event that it wanted to start human testing by the end of 2020. Receiving the breakthrough device designation from the FDA — designed to speed up the lengthy regulatory process — is a diflucan tablets buy step forward, but it by no means guarantees that a device will receive a green light, either in a short or longer-term time frame. After Musk’s presentation, a handful of the company’s employees — all wearing masks, but seated only inches apart — joined him to take questions submitted on Twitter or from the small audience in the room.In typical fashion for a man who in 2018 sent a Tesla Roadster into space, Musk didn’t hesitate to use the event to cross-promote his electric car company.

    Asked whether diflucan tablets buy the Neuralink chip would allow people to summon their Tesla telepathically, Musk responded. €œDefinitely — of course.”Matthew MacDougall, the company’s head neurosurgeon, appearing in scrubs, said the company had so far only implanted its technology into the brain’s cortical surface, the coaster-width layer enveloping the brain, but added that it hoped to go deeper in the future. Still, Musk said diflucan tablets buy. €œYou could solve blindness, you could solve paralysis, you could solve hearing — you can solve a lot just by interfacing with the cortex.”Musk and MacDougall said they hoped to eventually implant Neuralink’s devices — which they referred to on stage simply as “links” — in the deeper structures of the brain, such as in the hypothalamus, which is believed to play a critical role in mental illnesses including depression, anxiety, and PTSD.There were no updates at the event of Neuralink’s research in monkeys, which the company has been conducting in partnership with the University of California, Davis since 2017.

    At last July’s event, Musk said — without providing evidence — that a monkey had controlled a computer with its brain.At that diflucan tablets buy same July 2019 event, Neuralink released a preprint paper — published a few months later — that claimed to show that a series of Neuralink electrodes implanted in the brains of rats could record neural signals. Critically, the work did not show where in the brain the implanted electrodes were recording from, for how long they were recording, or whether the recordings could be linked to any of the rats’ bodily movements.In touting Friday’s event — and Neuralink’s technological capabilities — on Twitter in recent weeks, Musk spoke of “AI symbiosis while u wait” and referenced the “matrix in the matrix” — a science-fiction reference about revealing the true nature of reality. The progress the company reported on diflucan tablets buy Friday fell far short of that. Neuralink’s prototype is ambitious, but it has yet to show evidence that it can match up to the brain-machine interfaces developed by academic labs and other companies.

    Other groups have shown that they can listen in on neural activity and allow primates diflucan tablets buy and people to control a computer cursor with their brain — so-called “read-out” technology — and have also shown that they can use electrical stimulation to input information, such as a command or the heat of a hot cup of coffee, using “write-in” technology. Neuralink said on Friday that its technology would have both read-out and write-in capabilities.Musk acknowledged that Neuralink still has a long way to go. In closing diflucan tablets buy the event after more than 70 minutes, Musk said. €œThere’s a tremendous amount of work to be done to go from here to a device that is widely available and affordable and reliable.”Following the news this week of what appears to have been the first confirmed case of a antifungal medication re, other researchers have been coming forward with their own reports.

    One in Belgium, another in the Netherlands. And now, one in Nevada.What caught experts’ attention about the case of the 25-year-old Reno man was not that he diflucan tablets buy appears to have contracted antifungals (the name of the diflucan that causes antifungal medication) a second time. Rather, it’s that his second bout was more serious than his first.Immunologists had expected that if the immune response generated after an initial could not prevent a second case, then it should at least stave off more severe illness. That’s what diflucan tablets buy occurred with the first known re case, in a 33-year-old Hong Kong man.advertisement Still, despite what happened to the man in Nevada, researchers are stressing this is not a sky-is-falling situation or one that should result in firm conclusions.

    They always presumed people would become vulnerable to antifungal medication again some time after recovering from an initial case, based on how our immune systems respond to other respiratory diflucanes, including other antifungalses. It’s possible that these early diflucan tablets buy cases of re are outliers and have features that won’t apply to the tens of millions of other people who have already shaken off antifungal medication.“There are millions and millions of cases,” said Michael Mina, an epidemiologist at Harvard’s T.H. Chan School of Public Health. The real question that should get the most focus, Mina diflucan tablets buy said, is, “What happens to most people?.

    €advertisement But with more re reports likely to make it into the scientific literature soon, and from there into the mainstream press, here are some things to look for in assessing them.What’s the deal with the Nevada case?. The Reno resident in question first tested positive for antifungals in April after coming down with a sore throat, cough, diflucan tablets buy and headache, as well as nausea and diarrhea. He got better over time and later tested negative twice. But then, some 48 days later, the man started experiencing headaches, cough, and other symptoms diflucan tablets buy again.

    Eventually, he became so sick that he had to be hospitalized and was found to have pneumonia.Researchers sequenced diflucan samples from both of his s and found they were different, providing evidence that this was a new distinct from the first. What happens when we get antifungal medication in diflucan tablets buy the first case?. Researchers are finding that, generally, people who get antifungal medication develop a healthy immune response replete with both antibodies (molecules that can block pathogens from infecting cells) and T cells (which help wipe out the diflucan). This is what happens after other viral s.In addition to fending off the diflucan the diflucan tablets buy first time, that immune response also creates memories of the diflucan, should it try to invade a second time.

    It’s thought, then, that people who recover from antifungal medication will typically be protected from another case for some amount of time. With other antifungalses, protection is thought to last for perhaps a little less than a year to diflucan tablets buy about three years.But researchers can’t tell how long immunity will last with a new pathogen (like antifungals) until people start getting reinfected. They also don’t know exactly what mechanisms provide protection against antifungal medication, nor do they know what levels of antibodies or T cells are required to signal that someone is protected through a blood test. (These are called the “correlates of protection.”) Why do experts diflucan tablets buy expect second cases to be milder?.

    With other diflucanes, protective immunity doesn’t just vanish one day. Instead, it wanes over time diflucan tablets buy. Researchers have then hypothesized that with antifungals, perhaps our immune systems might not always be able to prevent it from getting a toehold in our cells — to halt entirely — but that it could still put up enough of a fight to guard us from getting really sick. Again, this is what happens with other respiratory pathogens.And it’s why some researchers actually looked at the Hong diflucan tablets buy Kong case with relief.

    The man had mild to moderate antifungal medication symptoms during the first case, but was asymptomatic the second time. It was a demonstration, experts said, of what you would diflucan tablets buy want your immune system to do. (The case was only detected because the man’s sample was taken at the airport when he arrived back in Hong Kong after traveling in Europe.)“The fact that somebody may get reinfected is not surprising,” Malik Peiris, a virologist at the University of Hong Kong, told STAT earlier this week about the first re. €œBut the re didn’t cause disease, so that’s the first point.”The Nevada case, then, provides a counterexample to that.

    What kind of immune diflucan tablets buy response did the person who was reinfected generate initially?. Earlier, we described the robust immune response that most people who have antifungal medication seem to mount. But that was a diflucan tablets buy generalization. s and the immune responses they induce in different people are “heterogeneous,” said Sarah Cobey, an epidemiologist and evolutionary biologist at the University of Chicago.Older people often generate weaker immune responses than younger people.

    Some studies have also indicated that milder cases of antifungal medication induce tamer immune responses diflucan tablets buy that might not provide as lasting or as thorough of a defense as stronger immune responses. The man in Hong Kong, for example, did not generate antibodies to the diflucan after his first , at least to the level that could be detected by blood tests. Perhaps that explains why he contracted the diflucan again just about 4 1/2 months after recovering from his initial .In the Nevada case, researchers did not test what kind of immune response the diflucan tablets buy man generated after the first case.“ is not some binary event,” Cobey said. And with re, “there’s going to be some viral replication, but the question is how much is the immune system getting engaged?.

    €What might be broadly meaningful is when people who mounted robust diflucan tablets buy immune responses start getting reinfected, and how severe their second cases are. Are people who have antifungal medication a second time infectious?. As discussed, diflucan tablets buy immune memory can prevent re. If it can’t, it might stave off serious illness.

    But there’s a third aspect of this, too.“The most important question for re, with the most serious implications for controlling the diflucan, is whether reinfected people can transmit the diflucan to others,” Columbia University virologist Angela Rasmussen wrote in Slate this diflucan tablets buy week.Unfortunately, neither the Hong Kong nor the Reno studies looked at this question. But if most people who get reinfected don’t spread the diflucan, that’s obviously good news. What happens when people broadly diflucan tablets buy become susceptible again?. Whether it’s six months after the first or nine months or a year or longer, at some point, protection for most people who recover from antifungal medication is expected to wane.

    And without the arrival of a treatment and broad uptake of it, that could change the dynamics of local outbreaks.In some communities, it’s thought that more than 20% of residents have experienced an initial antifungal medication case, and diflucan tablets buy are thus theoretically protected from another case for some time. That is still below the point of herd immunity — when enough people are immune that transmission doesn’t occur — but still, the fewer vulnerable people there are, the less likely spread is to occur.On the flip side though, if more people become susceptible to the diflucan again, that could increase the risk of transmission. Modelers are starting to factor that possibility into their forecasts.A crucial question for which there is not an answer yet is whether what happened to the man in Reno, where the second case diflucan tablets buy was more severe than the first, remains a rare occurrence, as researchers expect and hope. As the Nevada researchers wrote, “the generalizability of this finding is unknown.”An advocacy group has asked the Department of Defense to investigate what it called “an apparent failure” by Moderna (MRNA) to disclose millions of dollars in awards received from the Defense Advanced Research Projects Agency in patent applications the company filed for treatments.In a letter to the agency, Knowledge Ecology International explained that a review of dozens of patent applications found the company received approximately $20 million from the federal government in grants several years ago and the funds “likely” led to the creation of its treatment technology.

    This was used to develop treatments to combat different diflucanes, such as Zika and, later, the diflucan that causes diflucan tablets buy antifungal medication.In arguing for an investigation, the advocacy group maintained Moderna is obligated under federal law to disclose the grants that led to nearly a dozen specific patent applications and explained the financial support means the U.S. Government would have certain rights over the patents. In other words, diflucan tablets buy U.S. Taxpayers would have an ownership stake in treatments developed by the company.advertisement “This clarifies the public’s right in the inventions,” said Jamie Love, who heads Knowledge Ecology International, a nonprofit that tracks patents and access to medicines issues.

    €œThe disclosure (also) changes the narrative about who has financed the inventive activity, often the most risky part of development.” One particular patent assigned to Moderna concerns methods and compositions that diflucan tablets buy can be used specifically against antifungalses, including antifungal medication. The patent names a Moderna scientist and a former Moderna scientist as inventors, both of which acknowledged performing work under the DARPA awards in two academic papers, according to the report by the advocacy group.advertisement The group examined the 126 patents assigned to Moderna or ModernaTx as well as 154 patent applications. €œDespite the evidence that multiple inventions were conceived in the course of research supported by the DARPA awards, not a single one of the patents or applications assigned to Moderna disclose U.S. Federal government funding,” the report diflucan tablets buy stated.[UPDATE.

    A DARPA spokesman sent us this over the weekend. €œIt appears that all past and present DARPA awards to Moderna include the requirement to report the role of government diflucan tablets buy funding for related inventions. Further, DARPA is actively researching agency awards to Moderna to identify which patents and pending patents, if any at all, may be associated with DARPA support. This effort is ongoing.”]We asked Moderna for comment and will update you accordingly.The missive to the Department of Defense follows a recent analysis by Public Citizen, another advocacy group, indicating the National Institutes of Health may own mRNA-1273, diflucan tablets buy the Moderna treatment candidate for antifungal medication.

    The advocacy group noted the federal government filed multiple patents covering the treatment and two patent applications, in particular, list federal scientists as co-inventors.The analyses are part of a larger campaign among advocacy groups and others in the U.S. And elsewhere to ensure diflucan tablets buy that antifungal medication medical products are available to poor populations around the world. The concern reflects the unprecedented global demand for therapies and treatments, and a race among wealthy nations to snap up supplies from treatment makers. In the U.S., the effort has focused on the extent to which diflucan tablets buy the federal government has provided taxpayer dollars to different companies to help fund their discoveries.

    In some cases, advocates argue that federal funding matters because it clarifies the rights that the U.S. Government has to ensure a therapy or treatment is diflucan tablets buy available to Americans on reasonable terms.One example has been remdesivir, the Gilead Sciences (GILD) treatment being given to hospitalized antifungal medication patients. The role played by the U.S. Government in developing diflucan tablets buy remdesivir to combat antifungalses involved contributions from government personnel at such agencies as the U.S.

    Army Medical Research Institute of Infectious Diseases.As for the Moderna treatment, earlier this month, the company was awarded a $1.525 billion contract by the Department of Defense and the Department of Health and Human Services to manufacture and deliver 100 million doses of its antifungal medication treatment. The agreement also includes an option to purchase diflucan tablets buy another 400 million doses, although the terms were not disclosed. In announcing the agreement, the government said it would ensure Americans receive the antifungal medication treatment at no cost, although they may be charged by health care providers for administering a shot.In this instance, however, Love said the “letter is not about price or profits. It’s about diflucan tablets buy (Moderna) not owning up to DARPA funding inventions.

    If the U.S. Wants to pay for all of the development of Moderna’s treatment, as Moderna now acknowledges, and throw diflucan tablets buy in a few more billion now, and an option to spend billions more, it’s not unreasonable to have some transparency over who paid for their inventions.”This is not the first time Moderna has been accused of insufficient disclosure. Earlier this month, Knowledge Ecology International and Public Citizen maintained the company failed to disclose development costs in a $955 million contract awarded by BARDA for its antifungal medication treatment. In all, the federal government has awarded the company approximately $2.5 billion to develop the treatment.The coming few weeks represent a crucial moment for an ambitious plan to try to secure antifungal medication treatments for roughly 170 countries diflucan tablets buy around the world without the deep pockets to compete for what will be scarce initial supplies.Under the plan, countries that want to pool resources to buy treatments must notify the World Health Organization and other organizers — Gavi, the treatment Alliance, as well as the Coalition for Epidemic Preparedness Innovations — of their intentions by Monday.

    That means it’s fish-or-cut-bait time for the so-called COVAX facility.Already, wealthy countries — the United States, the United Kingdom, Japan, Canada, and Australia, among others, as well as the European Union — have opted to buy their own treatment, signing bilateral contracts with manufacturers that have secured billions of doses of treatment already. That raises the possibility that less wealthy countries will be boxed out of supplies.advertisement And yet Richard Hatchett, the CEO of CEPI, insists there is a path to billions diflucan tablets buy of doses of treatment for the rest of the world in 2021. STAT spoke with Hatchett this week. A transcript of the conversation, lightly edited for diflucan tablets buy clarity and length, follows.

    You said this is a critical time for CEPI. Can you explain what needs to happen between now and mid-September for this joint purchasing approach to be a success?. Advertisement The critical moment is now for countries to commit to the COVAX facility, because that will enable us to secure ample quantities of treatment and then to be able to convey when that treatment is likely to become available based on current information.What we’re now here asking countries to do is to indicate their intent diflucan tablets buy to participate by Aug. 31, and to make a binding commitment by Sept.

    18. And to provide funds in support of that binding commitment by early October. Our negotiations with companies are already taking place and it will be important for us from a planning purpose that countries indicate their intent to participate.Those binding commitments we think will be sufficient to allow us to then secure the advance purchase agreements, particularly with those companies that don’t have a prior contractual obligation to COVAX. And then obviously, we need the funds to live up to those advance purchase agreements.Is it possible this thing could still fall apart?.

    There appears to be some concern COVAX has been boxed out by rich countries. There was always a possibility that there wouldn’t be sufficient uptake. But I think we’re very encouraged at this point by the level of commitment, both from countries that would be beneficiaries of the advance market commitment — that’s the lower-income, lower-middle-income countries — as well as the self-financing countries. To have over 170 countries expressing interest in participating — they see the value.We’re much more encouraged now that it’s not going to fall apart.

    We still need to bring it off to maximize its value. And we’re right at the crunch moment where countries are going to have to make these commitments. So, the next month is really absolutely critical to the facility. I am confident at this point that the world recognizes the value and wants it to work.I’ve been keeping tabs on advance purchase agreements that have been announced.

    And at this point, a small number of rich countries have nailed down a lot of treatment — more than 3 billion doses. How hard does that make your job?. The fact that they’re doing it creates anxiety among other countries. And that in itself can accelerate the pace.

    So, I’m not going to say that we’re not watching that with concern.I will say that for COVAX and the facility, this is absolutely critical moment. I think we still have a window of opportunity between now and mid-September — when we’re asking that the self-financing countries to make their commitments — to make the facility real and to make it work. Between doses that are committed to COVAX through the access agreements and other agreements — these are discussions with partners that CEPI has funded as well as partners that CEPI has not funded — we still see a pathway for COVAX to well over 3 billion doses in 2021.I think it’s really important to bear in mind is that there are at least a few countries — and I think the U.S. And the U.K.

    Most publicly — that may be in a situation of significant oversupply. I believe the U.S. And U.K. Numbers, if you add them together, would result in enough treatment for 600 million people to receive two doses of treatment each.

    And, you know, there is no possible way that the U.S. Or the U.K. Can use that much treatment.So, there may be a lot of extra supply that looks like it’s been tied up sloshing around later. I don’t think that the bilateral deals that have been struck are going to prevent COVAX from achieving its goals.But if so much treatment has been pre-ordered by rich countries, can countries in the COVAX pool get enough for their needs?.

    One of the things that we’ve argued through COVAX is that to control the diflucan or to end the acute phase of the diflucan to allow normalcy to start to reassert itself, you don’t have to vaccinate 100% of your population.You need to vaccinate those at greatest risk for bad outcomes and you need to vaccinate certain critical workers, particularly your health care workforce. And if you can achieve that goal, which for most countries means vaccinating between 20% and maybe 30% of the population, then you can transform the diflucan into something that is much more manageable. Then you can buy yourself time to vaccinate everybody who wants to be vaccinated.We’ve argued the COVAX facility really offers the world the best shot at doing that globally in the fastest possible way, as well as providing for equitable access. This is a case where doing the equitable thing is also doing the efficient thing.CEPI has provided funding to nine treatments.

    Is it true that all those manufacturers aren’t required to provide the COVAX facility with treatment?. That is correct. One of the things that we did, and I think it was an important role that CEPI played early on, was that we moved money very, very quickly, in small increments. You know, some of the early contracts were only $5 million or $10 million, to get programs up and running while we potentially put in place much larger-scale, longer-term contracts.If you were doing it over again, would you have given money without strings attached?.

    Yes, I think I would have. I think that was critically important to initiating programs.Our contract with Moderna was established in about 48 hours. And that provided critical funding to them to manufacture doses that got them into clinical trials within nine weeks of the genetic sequences [of the antifungals diflucan] being released.And if you look at the nine programs that we’ve invested in, seven are in clinical trials. Two — the AstraZeneca program now and the Moderna program — are among the handful in Phase 3 clinical trials.

    And, I think the number of projects that that we funded initially, which started in kind of a biotech or academic phase that have now been picked up by large multinational corporations, there’s at least four. The Themis program being picked up by Merck, Oxford University by AstraZeneca, the University of Queensland by CSL, and Clover being in partnership with GSK, I think that speaks to the quality of the programs that we selected.So, I think that combination of rapid review, speed of funding, getting those programs started, getting them oriented in the right direction, I think all of that is critical to where we are now.Companies that got money from CEPI to build out production capacity — that money came with strings attached, right?. Yes, exactly. So, where CEPI has made investments that create manufacturing, or secure manufacturing capacity, the commitment has been that the capacity that is attributable to the CEPI investment is committed — at least right of first refusal — to the global procurement facility.WASHINGTON — The Trump administration removed a top Food and Drug Administration communications official from her post on Friday in the wake of several controversial agency misstatements, a senior administration official confirmed to STAT.The spokeswoman, Emily Miller, had played a lead role in defending the FDA commissioner, Stephen Hahn, after he misrepresented data regarding the use of blood plasma from recovered antifungal medication patients.

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    TTHealthWatch is a weekly podcast http://karenthefengshuilady.com/2010/10/07/are-you-ready/ from Texas yeast medication prescription diflucan Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center in El Paso, look at the top medical stories of the week. A transcript of the podcast is below the summary.This week's topics include face masks yeast medication prescription diflucan in Kansas, WHO recommendations on remdesivir, rate of HIV-related death, and delirium in older folks with antifungal medication.Program notes:0:44 Face masks in Kansas and antifungal medication1:44 Seven day average decreased 6%2:45 This study seems unlikely to change behavior3:44 Rate of delirium in older patients with antifungal medication in the ED4:41 Increased odds of ICU admission and death5:41 May be only symptom6:48 WHO recommendations about remdesivir7:48 Does it improve survival?.

    8:42 Resource rich areas9:45 Data from AstraZeneca treatment10:44 mRNA treatments more expensive11:15 Rates of death in those with HIV12:15 Rate decreased by 37%13:10 EndTranscript:Elizabeth Tracey. How often does delirium happen in older people who come to the ED with antifungal medication?. Rick Lange yeast medication prescription diflucan.

    What's the World Health Organization's recommendation for remdesivir?. Elizabeth. Good news yeast medication prescription diflucan about HIV-related death.Rick.

    And what can Kansas teach us about wearing masks to prevent antifungal medication ?. Elizabeth. That's what we're talking about this week on yeast medication prescription diflucan TT HealthWatch, your weekly look at the medical headlines from Texas Tech University Health Sciences Center in El Paso.

    I'm Elizabeth Tracey, a Baltimore-based medical journalist.Rick. And I'm Rick Lange, President of Texas Tech University Health Sciences Center in El Paso, where I'm also the Dean of the Paul L. Foster School yeast medication prescription diflucan of Medicine.Elizabeth.

    Rick, since you're pretty close to Kansas out there in Texas, why don't we start with what can they teach us about face masks?. That's in Morbidity and Mortality Weekly Report.Rick. Right.

    This is a report from the Centers for Disease Control and Prevention that talks about the trends in the county-level antifungal medication incidence in counties with and without a mask mandate in Kansas between June 1st and August 23rd.What happened was on July 2nd, the governor of Kansas issued an executive order -- this is a state mandate -- that was effective the next day that required masks or other face coverings in public spaces. But in Kansas, as a result of a rule that was passed earlier, the counties can either opt in to follow the governor's mandate or decide not to.As of August 11th, 24 of Kansas' 105 counties did not opt out of the state mandate, whereas the rest of them did. What happens to antifungal medication in the counties that did use the mask mandate and those that didn't?.

    Those that opted to follow the governor's recommendation -- and by the way, that accounted for about two-thirds of the state's population -- the 7-day average number of new daily cases decreased a net 6%. What happened in the counties that didn't do it?. Well, they had an increase of 100%.Now, the nice thing about this particular trial is they didn't have to adjust for various things like whether it was urban or rural.

    It's just an observational study in a state that otherwise didn't do anything significantly different other than either opt in or opt out of a mask mandate.Elizabeth. Of course, they had the other recommendations in place also with regard to physical distancing and crowd size, and all the rest of that, right?. Rick.

    Absolutely. Now, one could argue that maybe the places that followed the mask mandate were more vigilant about the other things. But actually, when you look at the data from June until July, until the mask mandate, the numbers increased substantially in all the counties, but it even increased more in those counties that later adopted the mask mandate.

    None of those things changed at all, the prevention measures that you describe. What primarily changed was the use or the non-use of masks.Elizabeth. I'm sorry to wax cynical here.

    However, I am going to comment that this study seems a lot like preaching to the choir to me. I think that everybody who is even peripherally involved with medicine is pretty convinced that masks are the right thing to do. I'm not sure that this is going to motivate those who are convicted that they are not going to wear a mask to change their behavior.Rick.

    And I agree with you. You might say, "Well, this is kind of a no-brainer." But obviously three-fourths of the counties in Kansas didn't believe it was a no-brainer and we still have a lot of people around the United States that really question the value of masks, especially if you're not using an N95.So apropos to this particular report, they've also put out recommendations and data regarding mask use across the United States in various places, because some people are unconvinced. I know you're convinced and I'm convinced, but there are still many people around the United States -- many of them leading legislative bodies in the United States -- that really don't believe in it.

    Believe it or not, some of them even live in Texas.Elizabeth. On that note, let's turn to JAMA Network Open. This is a study taking a look at how often does delirium occur in older patients with antifungal medication when they present to the ED?.

    Delirium, of course, we know is a really huge problem in older people and this study -- it's a retrospective study, really, looking at 817 older patients with antifungal medication who came to EDs spread throughout the whole country, and their average age was 77.7 years. Of those, 28% had delirium at presentation. It was the sixth most common of all presenting symptoms and signs in this population.Among those with delirium, 16% had delirium as a primary symptom and 37% had no typical antifungal medication symptoms or signs such as fever or shortness of breath.

    To me, that's really important. They also noticed that delirium was associated with increased odds of being admitted to the intensive care unit and dying. So clearly, when older people come to the ED, even if their only presentation is delirium, antifungal medication is really an important thing to be looking for.Rick.

    Elizabeth, several things about this study that I found were kind of interesting. This data has geographic importance. When you look at the antifungal medication data, even though people over the age of 65 only make up about 16% of the population, they represent 80% of the antifungal medication-related deaths in the United States, so identifying these individuals early and establishing treatment is important.

    What you don't want to do is you don't want to miss a diagnosis, and usually we think about things like fever and shortness of breath and fatigue as being major symptoms. But as you described, about one in eight of these individuals presented with just delirium, and nothing but delirium.By the way, in this study, many of those individuals had delirium for a protracted period of time, even up to as long as a week when they recognized they were sick. In older individuals, as you noted, this may be the only symptom because their immune system is somewhat suppressed and their baseline temperature is lower than younger individuals, so they don't manifest the usual symptoms.Elizabeth.

    They also note in here that this rate of delirium in this cohort is higher than has been reported in ED studies that were done before antifungal medication, where they assessed that rate of delirium. The other thing that they note is that there's a high occurrence of delirium and other neuropsychiatric manifestations with antifungal medication even among younger people.Rick. You're right.

    We've talked before about brain fog that occurs with antifungal medication even afterwards. We've looked at delirium in the hospital, and in fact, we estimated that about 25% to 33% of hospitalized patients diflucan 150mg price with antifungal medication have delirium, and even 65% of those in the intensive care unit. But this is a unique population -- these are older individuals that haven't been hospitalized.

    We're talking about how often is delirium their initial and sometimes only manifestation. This is a unique study and the data are really pretty important for caring for older individuals that may be antifungal medication-infected.Elizabeth. Let's turn to the British Medical Journal, where you served this up, about what is the WHO saying about remdesivir?.

    Rick. The World Health Organization is providing a living guidance that focuses on different treatments for antifungal medication. This is their second version.

    The first version looked at the use of steroids. This particular one looked at the use of remdesivir.The panel emphasized that the evidence suggests that there is no important effect on mortality, need for mechanical ventilation, time to clinical improvement, or other what they called "patient-important outcomes." Based upon the low certainty that it was beneficial and the fact that it could possibly have some harm, the panel said that the current evidence doesn't support patient-important outcomes.Let me take a step back because we're obviously using it in our hospital setting and many places around the United States. I want to focus on what they called patient-important outcomes.

    Because you and I would both agree that if we have a disease, things that may be important to us are. Does the treatment improve survival, or does it make me feel better, or do I improve quicker?. The data with remdesivir doesn't necessarily show that, but what it did show was it decreased hospital stays for individuals.Now, that may not be an important patient outcome, but I can tell you, especially in our setting in El Paso and other places around the United States, it's a very important outcome because as the number of cases increases, it overwhelms our system -- that is, our facilities and staff as well.While this may not be an important patient-centered outcome, it's an important community outcome, even though the WHO says, "Listen, based upon how the patient feels and availability and cost, is the evidence strong for it?.

    " They said, "Well, we can't exclude that it's beneficial, but the data aren't very supportive." From our standpoint, remdesivir does have an important role. The important role is freeing up hospital facilities and staff for other individuals that may have antifungal medication .Elizabeth. Clearly, we are in a resource-rich environment, and so the fact that remdesivir is utilized here in the United States is not surprising, and I think part of the WHO's reluctance to say, "Yeah, we're going to say this is good stuff" is because of the cost.Rick.

    You're right, Elizabeth. It's due to the cost of the medication. It is due to availability as well.

    It does require an intravenous infusion and it's limited to hospitalized patients, those that aren't sick enough to need steroids, but it's not used on an outpatient basis. So, you're right. By the way, they came down pretty salty and said we can't rule out a benefit, but we can't prove it as well.Now, we call ourselves resource-rich, and that's true, but the resources are finite.

    Again, in El Paso we happen to be at the epicenter of the diflucan and we've overwhelmed our hospital facilities and our staff. We've had to bring in mobile units and bring in outside staff as well. So if we can get people out of the hospital quicker, then any therapy that does that's beneficial.Elizabeth.

    Let's just mention, because this seems like an appropriate time to do so, that we're recording on Monday because of the Thanksgiving holiday. We have data from the AstraZeneca treatment that was published in the British Medical Journal also, I believe, that shows that it's 90.9% effective. Now, I thought that was really interesting.They had two treatment regimens, both requiring two doses of the treatment.

    One regimen was less effective. That was two full doses of the treatment. The one that was more effective was half dose followed by a full dose, so I thought that was a real curiosity and I'm going to be very interested to see what happens in post-marketing surveillance.Rick.

    A couple of things about these treatments. The Pfizer treatment, obviously mRNA treatment, it has to be stored in super cold facilities and it will have limited access worldwide. The AstraZeneca treatment is a chimpanzee adenodiflucan -- inactivated diflucan -- treatment.

    It doesn't require the extreme cold. It can be stored in a refrigerator and it will be available globally, and it will be substantially cheaper. That will be about $4 to $5 per dose, whereas the other treatments, the Pfizer and Moderna treatments, will probably range between $20 and $35 per dose.

    Again, all these treatments require two doses, so you can double that cost per person.So stay tuned. The Pfizer treatments should be available for distribution in the United States the second week in December. The AstraZeneca dose, first of all, it hasn't received EUA designation by the FDA or been approved worldwide yet, but it should be available fairly soon because there are more than ten countries that will be manufacturing the AstraZeneca Oxford treatment.Elizabeth.

    Good news, and we're going to end with some good news. This is back to Morbidity and Mortality Weekly Report. This is taking a look at trends regarding death among people with diagnosed HIV in the United States between 2010 and 2018.

    Those HIV-related deaths have decreased almost 49% -- 48.4%, which is really fabulous, fabulous news.The bad news, of course, is that that rate of decrease was highest in the Northeast -- so more people are getting diagnosed, getting treated, getting on medicines, staying on them and so forth -- and unfortunately was lowest in the South. It's clearly pointing to places where we need to make sure that people get tested, they find out their status, and then they get on these medicines, which we know really do suppress HIV and render people who have the diflucan almost able to have a normal lifespan.Rick. Elizabeth, as you mentioned, this is great news and since 2010 we've seen the death rate among these individuals in the U.S.

    Decrease by 37%. We targeted 33%, by the way, so this is even better than we expected.There are still some disparities, as you mentioned. More deaths in the South than the North and more among African-Americans than other ethnicities.

    That gap is closing over the years, and again, it's due to early identification, early testing, and early treatment as well. For those of us who trained in the era where there was no treatment and this was a death sentence, knowing that these individuals can have a nearly normal lifespan -- that's terrific news.Elizabeth. It is indeed.

    On that note, Happy Thanksgiving to all. This is definitely something to be thankful for, hopefully a model for how we're going to manage with antifungal medication. That's a look at this week's medical headlines from Texas Tech.

    I'm Elizabeth Tracey.Rick. So stay safe and y'all listen up make healthy choices..

    TTHealthWatch is diflucan tablets buy a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center in El Paso, look at the top medical stories of the week. A transcript of the podcast is below the summary.This week's topics include face masks in Kansas, WHO recommendations on remdesivir, rate of HIV-related death, and delirium in older folks with antifungal medication.Program notes:0:44 Face masks in Kansas and antifungal medication1:44 Seven day average decreased 6%2:45 This study seems unlikely to change behavior3:44 Rate of delirium in older patients with antifungal medication in the diflucan tablets buy ED4:41 Increased odds of ICU admission and death5:41 May be only symptom6:48 WHO recommendations about remdesivir7:48 Does it improve survival?. 8:42 Resource rich areas9:45 Data from AstraZeneca treatment10:44 mRNA treatments more expensive11:15 Rates of death in those with HIV12:15 Rate decreased by 37%13:10 EndTranscript:Elizabeth Tracey.

    How often does delirium happen in older people who come to the ED with antifungal medication?. Rick Lange diflucan tablets buy. What's the World Health Organization's recommendation for remdesivir?. Elizabeth.

    Good news about HIV-related death.Rick diflucan tablets buy. And what can Kansas teach us about wearing masks to prevent antifungal medication ?. Elizabeth. That's what we're talking diflucan tablets buy about this week on TT HealthWatch, your weekly look at the medical headlines from Texas Tech University Health Sciences Center in El Paso.

    I'm Elizabeth Tracey, a Baltimore-based medical journalist.Rick. And I'm Rick Lange, President of Texas Tech University Health Sciences Center in El Paso, where I'm also the Dean of the Paul L. Foster School of Medicine.Elizabeth diflucan tablets buy. Rick, since you're pretty close to Kansas out there in Texas, why don't we start with what can they teach us about face masks?.

    That's in Morbidity and Mortality Weekly Report.Rick. Right. This is a report from the Centers for Disease Control and Prevention that talks about the trends in the county-level antifungal medication incidence in counties with and without a mask mandate in Kansas between June 1st and August 23rd.What happened was on July 2nd, the governor of Kansas issued an executive order -- this is a state mandate -- that was effective the next day that required masks or other face coverings in public spaces. But in Kansas, as a result of a rule that was passed earlier, the counties can either opt in to follow the governor's mandate or decide not to.As of August 11th, 24 of Kansas' 105 counties did not opt out of the state mandate, whereas the rest of them did.

    What happens to antifungal medication in the counties that did use the mask mandate and those that didn't?. Those that opted to follow the governor's recommendation -- and by the way, that accounted for about two-thirds of the state's population -- the 7-day average number of new daily cases decreased a net 6%. What happened in the counties that didn't do it?. Well, they had an increase of 100%.Now, the nice thing about this particular trial is they didn't have to adjust for various things like whether it was urban or rural.

    It's just an observational study in a state that otherwise didn't do anything significantly different other than either opt in or opt out of a mask mandate.Elizabeth. Of course, they had the other recommendations in place also with regard to physical distancing and crowd size, and all the rest of that, right?. Rick. Absolutely.

    Now, one could argue that maybe the places that followed the mask mandate were more vigilant about the other things. But actually, when you look at the data from June until July, until the mask mandate, the numbers increased substantially in all the counties, but it even increased more in those counties that later adopted the mask mandate. None of those things changed at all, the prevention measures that you describe. What primarily changed was the use or the non-use of masks.Elizabeth.

    I'm sorry to wax cynical here. However, I am going to comment that this study seems a lot like preaching to the choir to me. I think that everybody who is even peripherally involved with medicine is pretty convinced that masks are the right thing to do. I'm not sure that this is going to motivate those who are convicted that they are not going to wear a mask to change their behavior.Rick.

    And I agree with you. You might say, "Well, this is kind of a no-brainer." But obviously three-fourths of the counties in Kansas didn't believe it was a no-brainer and we still have a lot of people around the United States that really question the value of masks, especially if you're not using an N95.So apropos to this particular report, they've also put out recommendations and data regarding mask use across the United States in various places, because some people are unconvinced. I know you're convinced and I'm convinced, but there are still many people around the United States -- many of them leading legislative bodies in the United States -- that really don't believe in it. Believe it or not, some of them even live in Texas.Elizabeth.

    On that note, let's turn to JAMA Network Open. This is a study taking a look at how often does delirium occur in older patients with antifungal medication when they present to the ED?. Delirium, of course, we know is a really huge problem in older people and this study -- it's a retrospective study, really, looking at 817 older patients with antifungal medication who came to EDs spread throughout the whole country, and their average age was 77.7 years. Of those, 28% had delirium at presentation.

    It was the sixth most common of all presenting symptoms and signs in this population.Among those with delirium, 16% had delirium as a primary symptom and 37% had no typical antifungal medication symptoms or signs such as fever or shortness of breath. To me, that's really important. They also noticed that delirium was associated with increased odds of being admitted to the intensive care unit and dying. So clearly, when older people come to the ED, even if their only presentation is delirium, antifungal medication is really an important thing to be looking for.Rick.

    Elizabeth, several things about this study that I found were kind of interesting. This data has geographic importance. When you look at the antifungal medication data, even though people over the age of 65 only make up about 16% of the population, they represent 80% of the antifungal medication-related deaths in the United States, so identifying these individuals early and establishing treatment is important. What you don't want to do is you don't want to miss a diagnosis, and usually we think about things like fever and shortness of breath and fatigue as being major symptoms.

    But as you described, about one in eight of these individuals presented with just delirium, and nothing but delirium.By the way, in this study, many of those individuals had delirium for a protracted period of time, even up to as long as a week when they recognized they were sick. In older individuals, as you noted, this may be the only symptom because their immune system is somewhat suppressed and their baseline temperature is lower than younger individuals, so they don't manifest the usual symptoms.Elizabeth. They also note in here that this rate of delirium in this cohort is higher than has been reported in ED studies that were done before antifungal medication, where they assessed that rate of delirium. The other thing that they note is that there's a high occurrence of delirium and other neuropsychiatric manifestations with antifungal medication even among younger people.Rick.

    You're right. We've talked before about brain fog that occurs with antifungal medication even afterwards. We've looked at delirium in the hospital, and in fact, we estimated that about 25% to 33% of hospitalized patients with antifungal medication have delirium, and even 65% of those in the intensive care unit. But this is a unique population -- these are older individuals that haven't been hospitalized.

    We're talking about how often is delirium their initial and sometimes only manifestation. This is a unique study and the data are really pretty important for caring for older individuals that may be antifungal medication-infected.Elizabeth. Let's turn to the British Medical Journal, where you served this up, about what is the WHO saying about remdesivir?. Rick.

    The World Health Organization is providing a living guidance that focuses on different treatments for antifungal medication. This is their second version. The first version looked at the use of steroids. This particular one looked at the use of remdesivir.The panel emphasized that the evidence suggests that there is no important effect on mortality, need for mechanical ventilation, time to clinical improvement, or other what they called "patient-important outcomes." Based upon the low certainty that it was beneficial and the fact that it could possibly have some harm, the panel said that the current evidence doesn't support patient-important outcomes.Let me take a step back because we're obviously using it in our hospital setting and many places around the United States.

    I want to focus on what they called patient-important outcomes. Because you and I would both agree that if we have a disease, things that may be important to us are. Does the treatment improve survival, or does it make me feel better, or do I improve quicker?. The data with remdesivir doesn't necessarily show that, but what it did show was it decreased hospital stays for individuals.Now, that may not be an important patient outcome, but I can tell you, especially in our setting in El Paso and other places around the United States, it's a very important outcome because as the number of cases increases, it overwhelms our system -- that is, our facilities and staff as well.While this may not be an important patient-centered outcome, it's an important community outcome, even though the WHO says, "Listen, based upon how the patient feels and availability and cost, is the evidence strong for it?.

    " They said, "Well, we can't exclude that it's beneficial, but the data aren't very supportive." From our standpoint, remdesivir does have an important role. The important role is freeing up hospital facilities and staff for other individuals that may have antifungal medication .Elizabeth. Clearly, we are in a resource-rich environment, and so the fact that remdesivir is utilized here in the United States is not surprising, and I think part of the WHO's reluctance to say, "Yeah, we're going to say this is good stuff" is because of the cost.Rick. You're right, Elizabeth.

    It's due to the cost of the medication. It is due to availability as well. It does require an intravenous infusion and it's limited to hospitalized patients, those that aren't sick enough to need steroids, but it's not used on an outpatient basis. So, you're right.

    By the way, they came down pretty salty and said we can't rule out a benefit, but we can't prove it as well.Now, we call ourselves resource-rich, and that's true, but the resources are finite. Again, in El Paso we happen to be at the epicenter of the diflucan and we've overwhelmed our hospital facilities and our staff. We've had to bring in mobile units and bring in outside staff as well. So if we can get people out of the hospital quicker, then any therapy that does that's beneficial.Elizabeth.

    Let's just mention, because this seems like an appropriate time to do so, that we're recording on Monday because of the Thanksgiving holiday. We have data from the AstraZeneca treatment that was published in the British Medical Journal also, I believe, that shows that it's 90.9% effective. Now, I thought that was really interesting.They had two treatment regimens, both requiring two doses of the treatment. One regimen was less effective.

    That was two full doses of the treatment. The one that was more effective was half dose followed by a full dose, so I thought that was a real curiosity and I'm going to be very interested to see what happens in post-marketing surveillance.Rick. A couple of things about these treatments. The Pfizer treatment, obviously mRNA treatment, it has to be stored in super cold facilities and it will have limited access worldwide.

    The AstraZeneca treatment is a chimpanzee adenodiflucan -- inactivated diflucan -- treatment. It doesn't require the extreme cold. It can be stored in a refrigerator and it will be available globally, and it will be substantially cheaper. That will be about $4 to $5 per dose, whereas the other treatments, the Pfizer and Moderna treatments, will probably range between $20 and $35 per dose.

    Again, all these treatments require two doses, so you can double that cost per person.So stay tuned. The Pfizer treatments should be available for distribution in the United States the second week in December. The AstraZeneca dose, first of all, it hasn't received EUA designation by the FDA or been approved worldwide yet, but it should be available fairly soon because there are more than ten countries that will be manufacturing the AstraZeneca Oxford treatment.Elizabeth. Good news, and we're going to end with some good news.

    This is back to Morbidity and Mortality Weekly Report. This is taking a look at trends regarding death among people with diagnosed HIV in the United States between 2010 and 2018. Those HIV-related deaths have decreased almost 49% -- 48.4%, which is really fabulous, fabulous news.The bad news, of course, is that that rate of decrease was highest in the Northeast -- so more people are getting diagnosed, getting treated, getting on medicines, staying on them and so forth -- and unfortunately was lowest in the South. It's clearly pointing to places where we need to make sure that people get tested, they find out their status, and then they get on these medicines, which we know really do suppress HIV and render people who have the diflucan almost able to have a normal lifespan.Rick.

    Elizabeth, as you mentioned, this is great news and since 2010 we've seen the death rate among these individuals in the U.S. Decrease by 37%. We targeted 33%, by the way, so this is even better than we expected.There are still some disparities, as you mentioned. More deaths in the South than the North and more among African-Americans than other ethnicities.

    That gap is closing over the years, and again, it's due to early identification, early testing, and early treatment as well. For those of us who trained in the era where there was no treatment and this was a death sentence, knowing that these individuals can have a nearly normal lifespan -- that's terrific news.Elizabeth. It is indeed. On that note, Happy Thanksgiving to all.

    This is definitely something to be thankful for, hopefully a model for how we're going to manage with antifungal medication. That's a look at this week's medical headlines from Texas Tech. I'm Elizabeth Tracey.Rick. So stay safe and y'all listen up make healthy choices..

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